2003-2010 美国康涅狄格大学,博士
1999-2003 beat365体育亚洲唯一入口,学士
主要工作经历与任职情况
2022.06-至今 beat365体育亚洲唯一入口,教授
2014-2022.06 beat365体育亚洲唯一入口,副教授
2010-2014 美国华盛顿大学药理学系,博士后
主要社会兼职
2019-至今 中国生物化学与分子生物学会教学专业委员会第二届青年委员会委员
2016-2018中国生物化学与分子生物学会脂蛋白专业委员会第二届青年委员会委员
主要科研奖励和个人荣誉
beat365体育亚洲唯一入口优秀导航师(2016)
beat365体育亚洲唯一入口优秀本科教学奖(2017)
beat365体育亚洲唯一入口珞珈青年学者(2017)
弘毅学堂优秀教育工作者(2022)
承担课程
本科生:《专业文献研读》、《生物化学》、《自然科学经典导引》
研究生:《科研写作与学术伦理》
主持课题项目
1)国自然面上项目:过氧化物酶体介导的胆固醇从溶酶体向内质网的转运及分子机制研究(2018/01至2021/12)
2)国自然青年基金:调控LDLR蛋白稳定性的去泛素化酶的鉴定、作用机制与功能研究(2017/01至2019/12)
主要研究领域及兴趣
低密度脂蛋白受体的稳定性调控与胆固醇代谢平衡和动脉粥样硬化的关系
代表性论文(#并列第一作者,*通讯作者)
1) Wang JK#, Li Y, Zhao X, Liu YB, Tan J, Xing YY, Adi D, Wang YT, Fu ZY, Ma YT, Liu SM, Liu Y, Wang Y, Shi XJ, Lu XY, Song BL*, Luo J*. Ablation of plasma prekallikrein decreases LDL cholesterol by stabilizing LDL receptor and protects against atherosclerosis. Circulation 145:675-687. (2022)
2) Adi D#, Lu XY#, Fu ZY#, Wei J, Baituola G, Meng YJ, Zhou YX, Hu A, Wang JK, LuXF, Wang Y, Song BL, Ma YT*, Luo J*. IDOL G51S variant is associated with high blood cholesterol and increases low-density lipoprotein receptor degradation. Arterioscler Thromb Vasc Biol. 39(12):2468-2479. (2019)
3) Li BT#, Sun M, Li YF, Wang JQ, Zhou ZM, Song BL, Luo J*. Disruption of the ERLIN-TM6SF2-APOB complex destabilizes APOB and contributes to non-alcoholic fatty liver disease. PLoS Genet. 16(8):e1008955. (2020)
4) Jiang SY#, Tang JJ#, Xiao X, Qi W, Wu S, Jiang C, Hong J, Xu J*, Song BL*, Luo J*. Schnyder corneal dystrophy-associated UBIAD1 mutations cause corneal cholesterol accumulation by stabilizing HMG-CoA reductase. PLoS Genet. 15(7):e1008289. (2019)
5) Li, MX#, Yang Y#, Zhao, Q, Wu, Y, Song, L, Yang, H, He, M, Gao, H, Song, BL, Luo J*, Rao, Y*. Degradation versus inhibition: development of proteolysis-targeting chimeras for overcoming statin-induced compensatory upregulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase. J Med Chem. 63(9):4908-4928. (2020)
6) Luo J#, Yang H, Song BL*. Mechanisms and regulation of cholesterol homeostasis. Nat Rev Mol Cell Biol. 21(4):225-245. (2020)
7) Xiao J#, Xiong YN, Yang LT, Wang JQ, Zhou ZM, Dong LW, Shi XJ, Zhao XL, Luo J*, Song BL*. POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation. Protein Cell 12(4):279-296. (2021)
8) Wang JQ#, Lin ZC, Li LL, Zhang SF, Li WH, Liu W, Song BL, Luo J*. SUMOylation of the ubiquitin ligase IDOL decreases LDL receptor levels and is reversed by SENP1. J Biol Chem. 296:100032. (2021)
9) Xiao J#, Luo J#, Hu A, Xiao T, Li M, Kong Z, Jiang L, Zhou Z, Liao Y, Xie C, Chu B, Miao H, Li B, Shi X, Song BL*. Cholesterol transport through the peroxisome-ER membrane contacts tethered by PI(4,5)P2 and extended synaptotagmins. Sci China Life Sci. 62(9):1117-1135. (2019)
10) Hu A#, Zhao XT, Tu H, Xiao T, Fu T, Wang Y, Liu Y, Shi XJ, Luo J*, Song BL*. PIP4K2A regulates intracellular cholesterol transport through modulating PI(4,5)P2 homeostasis. J Lipid Res. 59(3): 507-514. (2018)